HCID 18457001, compound → HCID 17856264, compound

HRID 1351797Notes

Reaction equation

HRID 1351797 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([CH:15]([CH3:17])[CH3:16])[CH:12]=[CH:11][C:10]=1[CH2:18][CH2:19][NH:20][S:21]([C:24]1[CH:29]=[C:28]([C:30]#[N:31])[CH:27]=[CH:26][C:25]=1[OH:32])(=[O:23])=[O:22])C1C=CC=CC=1>C(O)C.[Pd]>[C:30]([C:28]1[CH:27]=[CH:26][C:25]([OH:32])=[C:24]([S:21]([NH:20][CH2:19][CH2:18][C:10]2[CH:11]=[CH:12][C:13]([CH:15]([CH3:17])[CH3:16])=[CH:14][C:9]=2[OH:8])(=[O:23])=[O:22])[CH:29]=1)#[N:31]

Participants

4

Reactant 1

HCID 18457001HCID 18457001, compound

Product 1

HCID 17856264HCID 17856264, compoundYield 88.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a stirred solution of 0.203 g of N-[2-(2-benzyloxy-4-isopropylphenyl)ethyl]-5-cyano-2-hydroxybenzenesulfonamide in ethanol was added 0.04 g of 10% palladium on carbon, and the mixture was stirred under a hydrogen atmosphere and ordinary pressure for 3 hours. After the insoluble material was removed by filtration, the filtrate was concentrated under reduced pressure to give 0.143 g of 5-cyano-2-hydroxy-N-[2-(2-hydroxy-4-isopropylphenyl)ethyl]benzenesulfonamide.

Workup

  1. customAfter the insoluble material was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-a3998affb20a413a80e2c2e17e9f7ab7
Source dataset
uspto-grants-2007_05
Patent number
US07217832B2

Reaction notes

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