Sodium Hydroxide → HCID 69329963, compound

HRID 1351897Notes

Reaction equation

HRID 1351897 reaction equation
Cl.C[O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[CH2:15][CH2:14][CH2:13][CH:12]([NH:16][CH2:17][C@H:18]([OH:27])[CH2:19][O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:11][C:10]=2[CH:28]=1)=[O:5].[OH-].[Na+:30]>CO>[OH:27][C@H:18]([CH2:19][O:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[CH2:17][NH:16][CH:12]1[CH2:11][C:10]2[CH:28]=[C:6]([C:4]([O-:5])=[O:3])[CH:7]=[CH:8][C:9]=2[CH2:15][CH2:14][CH2:13]1.[Na+:30]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 69329974HCID 69329974, compound

Product 1

HCID 69329963HCID 69329963, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

8-[(2S)-2-Hydroxy-3-phenoxypropyl]amino-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-carboxylic acid methyl ester hydrochloride was converted to the corresponding free base in a usual manner. A solution of the base (91 mg) in methanol (1 ml) and 1N sodium hydroxide aqueous solution (0.246 ml) was stirred at 70° C. for 6 hours and evaporated in vacuo. The residue was triturated in diisopropyl ether, and the precipitated powder was collected by filtration to afford sodium 8-[(2S)-2-hydroxy-3-phenoxypropyl]amino-6,7,8,9-tetrahydro-5H-benzocycloheptene-2-carboxylate (74 mg).

Workup

  1. customevaporated in vacuo
  2. customThe residue was triturated in diisopropyl ether
  3. filtrationthe precipitated powder was collected by filtration

Sources & evidence

ORD record
ord-0e379b4fe4f14aeda2f3641b525ed91e
Source dataset
uspto-grants-2007_05
Patent number
US07217706B2

Reaction notes

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