HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → (R)-N-{2-[3-(2-aminopropyl)-1H-indol-7-yloxy]-acetyl}methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-butyl (R)-{2-[7-(2-methanesulfonylamino-2-oxo-ethoxy)-1H-indol-3-yl]-1-methylethyl}carbamate | HCID 86604018 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (R)-N-{2-[3-(2-aminopropyl)-1H-indol-7-yloxy]-acetyl}methanesulfonamide | HCID 69456022 | — |
Reaction Steps
A solution of tert-butyl (R)-{2-[7-(2-methanesulfonylamino-2-oxoethoxy)-1H-indol-3-yl]-1-methylethyl}carbamate (0.14 g, 0.33 mmol) and trifluoroacetic acid (1 mL) in methylene chloride (4 mL) is stirred at room temperature for 8 hours. The mixture is concentrated to give the desired (R)—N-{2-[3-(2-aminopropyl)-1H-indol-7-yloxy]acetyl}methane-sulfonamide.trifluoroacetate (0.13 g, yield: 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07217724B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-91750a80a6574322bb9f3af532d9ea83 |
| Source note | uspto-grants-2007_05 |