Hydrochloric Acid → HCID 69457383, compound

Participants

Reaction Steps

To a solution of ethyl (((3-(2-(((1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methylethyl)amino)ethyl)-1H-indol-7-yl)oxy)acetate (115 mg, 0.279 mmol) in tetrahydrofuran (5 mL) and water (0.5 mL) is added lithium hydroxide (10 mg, 0.418 mmol), and the mixture is stirred at room temperature for 11 hours. The pH value of the mixture is adjusted to pH 7 with 1N aqueous hydrochloric acid solution, and the solvent is distilled off. The obtained crude product is purified by octadecylsilyl (ODS) column chromatography (water→10% aqueous methanol) to give (((3-(2-(((1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)-1H-indol-7-yl)oxy)acetic acid (108 mg, 0.279 mmol, yield: 100%).

Provenance & Evidence