(R)-(+)-3-Chlorostyrene oxide → HCID 69455783, compound

Participants

Reaction Steps

To a solution of (R)-3-(2-aminopropyl)-1H-indole-6-carboxylic acid diethylamide (960 mg, 3.51 mmol) in acetonitrile (10 ml) is added (R)-(+)-3-chlorostyrene oxide (1.09 g, 7.02 mmol), and the mixture is refluxed for 5 hours. The reaction solution is concentrated under reduced pressure, and the residue is purified by silica gel column chromatography (chloroform/methanol=20/1→(a saturated ammonia solution in chloroform)/methanol=20/1) to give 3-{(2R)-2-[2-(3-chloro-phenyl)-(2R)-2-hydroxyethylamino]propyl}-1H-indole-6-carboxylic acid diethylamide (950 mg, 2.22 mmol, 63%).

Provenance & Evidence