Hydrochloric Acid → HCID 69456223, compound

Participants

Reaction Steps

To a solution of 3-{(2R)-2-[2-(3-chlorophenyl)-(2R)-2-hydroxy-ethylamino]propyl}-1H-indole-6-carboxylic acid diethylamide (800 mg, 1.87 mmol) in 1,4-dioxane (10 ml) is added 6N—HCl (10 ml), and the mixture is refluxed for 24 hours. After allowed to cool, the reaction solution is concentrated under reduced pressure, and the residue is purified by octadecylsilyl column chromatography (trifluoroacetic acid/methanol/water), and further crystallized from aqueous methanol (pH 7) to give 3-{(2R)-2-[2-(3-chlorophenyl)-(2R)-2-hydroxyethylamino]-propyl}-1H-indole-6-carboxylic acid (304 mg, 0.815 mmol, 44%) as white crystals.

Provenance & Evidence