(R)-N-[2-benzyloxy-5-(2-iodo-1-triethylsilyloxyethyl)phenyl]methanesulfonamide → HCID 69456203, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (R)-3-(2-aminopropyl)-1H-indole-6-carboxylic acid diethylamide (20.0 mg, 0.0742 mmol) in acetonitrile (1.0 ml) is added (R)—N-[2-benzyloxy-5-(2-iodo-1-triethylsilyloxyethyl)phenyl]-methanesulfonamide (41.1 mg, 0.0742 mmol), and the mixture is stirred at 110° C. for 21 hours in a sealed vessel. The reaction solution is concentrated under reduced pressure, and the residue is purified by preparative TLC (a saturated ammonia solution in chloroform/methanol=50/1) to give 3-{(2R)-2-[2-(4-benzyloxy-3-methanesulfonylamino-phenyl)-(2R)-2-(triethylsilyloxy) ethylamino]propyl}-1H-indole-6-carboxylic acid diethylamide (19.2 mg, 0.0272 mmol, 37%).

Provenance & Evidence