Hydrochloric Acid → HCID 69458988, compound

Participants

Reaction Steps

To a solution of ethyl 3-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-(methyl) ethylamino]ethyl}-1H-indole-7-carboxylate (115 mg, 0.301 mmol) in tetrahydrofuran (10 mL) and water (5 mL) is added lithium hydroxide (36 mg, 1.51 mmol), and the mixture is stirred at room temperature for 15 hours. The pH value of the reaction solution is adjusted to pH 7 with 1N aqueous hydrochloric acid solution, and the solvent is distilled off. The residue is isolated by reversed phase column (octadecylsilyl, water→water-methanol=10:1→9:1→6:1) to give 3-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-(methyl)ethyl-amino]ethyl}-1H-indole-7-carboxylic acid (69.3 mg, 0.195 mmol, 65%).

Provenance & Evidence