Ethanol → Ethyl 3-((2R)-2-{[(2 R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}propyl)-1H-indole-7-carboxylate

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Reaction Conditions

Reaction Steps

3-{(2R)-2-[2-(3-Chlorophenyl)-(2R)-2-hydroxyethylamino]propyl}-1H-indole-7-carboxylic acid (50 mg, 0.134 mmol) is dissolved in ethanol (5 mL), and thereto are added conc. sulfuric acid (0.05 mL) and Molecular Sieves 4A powder (trade name, 0.3 g), and the mixture is heated at 150° C. for 16 hours. After cooling, the insoluble materials are removed by filtration, and a saturated aqueous sodium hydrogen carbonate solution is added to the filtrate. The mixture is evaporated under reduced pressure to remove ethanol, and the resultant is extracted with ethyl acetate. The organic layer is washed with a saturated brine, dried over sodium sulfate, and concentrated. The residue is purified by silica gel column chromatography (chloroform/ethanol=4/1) to give the title compound (50 mg, yield: 93%).

Provenance & Evidence