Hydrochloric Acid → HCID 69457066, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 3-[(2R)-2-({(2R)-2-{4-(benzyloxy)-3-[(methylsulfonyl)amino]phenyl}-2-[(triethylsilyl)oxy]ethyl}amino)propyl]-1H-indole-7-carboxylate (400 mg, 0.601 mmol) in methanol (20 ml) is added a solution of potassium hydroxide (336 mg, 6.01 mmol) in water (2.0 ml), and the mixture is stirred at 40° C. for 9 hours. The reaction solution is neutralized with 1N hydrochloric acid at 0° C., and thereto is added a pH standard solution (pH 6.8, 5.0 ml). The resultant is purified by reversed phase column (octadecylsilyl, water/methanol 95/5→40/60) to give the title compound (296 mg, yield: 92%).

Provenance & Evidence