Sodium Bicarbonate → HCID 69459074, compound

Participants

Reaction Steps

Further, to a solution of tert-butyl (1R)-1-methyl-2-(7-(((1R)-1-methyl-2-morpholin-4-yl-2-oxoethyl)oxy)-1H-indol-3-yl)ethyl((2R)-2-pyridin-3-yl-2-((triethylsilyl)oxy)ethyl)carbamate (190 mg, 0.285 mmol) in ethanol (2.0 mL) is added a 4N hydrochloric acid/dioxane (2.0 mL, 8.0 mmol), and the mixture is stirred at room temperature for 14 hours. To the reaction solution are added a saturated aqueous sodium hydrogen carbonate solution and a saturated brine, and the mixture is extracted with chloroform, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography (a saturated ammonia solution in chloroform/methanol=100/1→100/4) to give the title compound (107 mg, yield: 83%).

Provenance & Evidence