Water → HCID 69459893, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(2-hydroxyethyl)-1H-indol-7-ol (1.05 g, 5.93 mmol) in N,N-dimethylformamide (20 mL) are added (1R)-1-methyl-2-morpholin-4-yl-2-oxoethyl-4-methylbenzenesulfonate (2.79 g, 8.90 mmol) and potassium carbonate (1.3 g, 9.41 mmol), and the mixture is stirred at 60° C. for 5 hours. The reaction solution is cooled to room temperature, and the mixture is poured into water. The mixture is extracted with ethyl acetate, and the organic layer is washed with a saturated aqueous sodium hydrogen carbonate solution, and dried over anhydrous sodium sulfate. The solvent is removed by distillation, and the obtained crude product is purified by silica gel column chromatography (chloroform→chloroform:methanol=50:1→30:1) to give the title compound (1.29 g, yield: 68%).

Provenance & Evidence