Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Carbon Tetrachloride → tert-Butyl 4-(bromomethyl)-1H-benzo[d]imidazole-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Carbon Tetrachloride | HCID 5943 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | t-butyl 4-methyl-1H-benzimidazole-1-carboxylate | HCID 15744963 | — |
| 생성물 | tert-Butyl 4-(bromomethyl)-1H-benzo[d]imidazole-1-carboxylate | HCID 15744964 | 42.4% |
반응 단계
A mixture of 4-methylbenzimidazole-1-carboxylic acid, 1,1-dimethylethyl ester (6.50 g, 28.0 mmol) and N-bromosuccinimide (5.50 g, 30.9 mmol) in carbon tetrachloride (75 mmol) was stirred and irradiated with a 250 W flood lamp for 1 h. The reaction mixture was allowed to cool and the solid was filtered off and discarded. The filtrate was evaporated and purified by HPLC (20% ethyl acetate/hexanes) to give 4-(bromomethyl)benzimidazole-1-carboxylic acid, 1,1-dimethylethyl ester (3.69 g, 42%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07217728B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-9a28564e9afe4838938692bab49bfad9 |
| 출처 메모 | uspto-grants-2007_05 |