1H-Indazol-5-amine → HCID 17838187, compound

HRID 1352119Notes

Reaction equation

HRID 1352119 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=1[N:19]=[C:20]=[O:21]>C1(C)C=CC=CC=1>[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[C:13]=1[NH:19][C:20]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2)=[O:21]

Participants

4

Reactant 2

HCID 880121H-Indazol-5-amineHCID 6045371,3-Dichloro-2-isocyanatobenzene

Product 1

HCID 17838187HCID 17838187, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
110 °C

Procedure

5-Aminoindazole (100 mg, 0.75 mmol) and 2,6-dichlorophenyl isocyanate (155.3 mg, 0.83 mmol, 1.1 eq) were dissolved in toluene, and the mixture was then stirred at 110° C. for 4 hr.

Sources & evidence

ORD record
ord-8ebbc8968a304a488909b76a75b01652
Source dataset
uspto-grants-2007_05
Patent number
US07217722B2

Reaction notes

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