Dimethylamine → HCID 17838209, compound

Participants

Reaction Steps

Dimethylamine (100 mg) and the compound prepared in Example 222 (350 mg) were dissolved in dimethylformamide (5 ml), and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (257 mg), 1-hydroxybenzotriazole (227 mg), and dimethylaminopyridine (5 mg) were added to the solution. The reaction mixture was stirred at room temperature for 18 hr. A saturated aqueous sodium hydrogencarbonate solution (5 ml) was then added thereto, and the mixture was extracted with chloroform-propanol (3/1). The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under the reduced pressure. The residue was purified by HPLC [chloroform/methanol]t to give 180 mg of the title compound as two diastereomers (ratio=ca. 50:50)).

Provenance & Evidence