Methanol → HCID 17838053, compound

Participants

Reaction Steps

1-Methyl-4-piperidone (300 mg) was dissolved in titanium tetraisopropoxide (1.5 g). 5-Aminoindazole (282 mg) was added to the solution, and the mixture was stirred at room temperature for 18 hr. Methanol and sodium borohydride (50 mg) were added to the reaction solution, and the mixture was stirred for 18 hr. The reaction solution was diluted with ethyl acetate, and a minor amount of water was added thereto, and the mixture was then filtered under the reduced pressure. The filtrate was concentrated under the reduced pressure, and the residue was purified by column chromatography on silica gel [chloroform/methanol] to give the title compound (202 mg, yield 41.4%).

Provenance & Evidence