反应详情

A 25 g of 1,5-dihydroxy-4,8-dinitroanthraquinone and a 25 g of 2-methylaniline were dissolved in 250 ml of dimethylacetamide. The solution was heated and allowed to react at an inner temperature of 140 degrees Celsius for 4 hours. The reaction solution was cooled, and then extracted with adequate amounts of ethyl acetate and 1N-hydrochrolic acid to separate into two layers. The extracted organic layer was dried with magnesium sulfate and then concentrated. The concentrated solution was purified by silica gel chromatography to give a 9.7 g of 8-(2′-methylanilino)-1,5-dihydroxy-4-nitroanthraquinone in a 33% yield.

1. temperatureThe solution was heated
2. customto react at an inner temperature of 140 degrees Celsius for 4 hours
3. temperatureThe reaction solution was cooled
4. extractionextracted with adequate amounts of ethyl acetate and 1N-hydrochrolic acid
5. customto separate into two layers
6. dry with materialThe extracted organic layer was dried with magnesium sulfate
7. concentrationconcentrated
8. customThe concentrated solution was purified by silica gel chromatography