3,4-dihydro-2H-pyran → 2-[(6-bromohexyl)oxy]tetrahydro-2H-pyran

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Reaction Steps

197.8 g (1.09 mol) 6-bromo-1-hexanol were given into a 500 ml reactor vessel and cooled to 5° C. or less. 102.1 g (1.21 mol) dihydropyran were added dropwise to this at a temperature of 10° C. or less. After dropping was finished, the mixture was returned to room temperature and stirred for one hour. The precipitate obtained in the reaction was purified in a silica gel column with hexane/IPE (diusopropyl ether)=5/1, resulting in 263.4 g of 6-bromo-1-(tetrahydropyranyloxy)hexane. The yield was 90.9%. The chemical formula for the reaction formula of Step 1 is shown below in equation (2).

Provenance & Evidence