4,5-dibromo-3-methylthiophene-2-carbaldehyde → HCID 178428510, compound

HRID 1352235Notes

Reaction equation

HRID 1352235 reaction equation
[N:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[NH:3][C:2]=1[NH:10][CH2:11][CH2:12][CH2:13][NH2:14].[Br:15][C:16]1[C:17]([CH3:24])=[C:18]([CH:22]=O)[S:19][C:20]=1[Br:21]>>[Br:15][C:16]1[C:17]([CH3:24])=[C:18]([CH2:22][NH:14][CH2:13][CH2:12][CH2:11][NH:10][C:2]2[NH:1][C:9]3[CH:8]=[CH:7][N:6]=[CH:5][C:4]=3[N:3]=2)[S:19][C:20]=1[Br:21]

Participants

3

Reactant 2

HCID 70963554,5-dibromo-3-methylthiophene-2-carbaldehydeHCID 22324424HCID 22324424, compound

Product 1

HCID 178428510HCID 178428510, compoundYield 49%

Procedure

Using the general method for reductive amination a mixture of N-(3H-imidazo[4,5-c]pyridin-2-yl)propane-1,3-diamine (0.037 g, 0.19 mmol) and 4,5-dibromo-3-methylthiophene-2-carbaldehyde (0.054 g, 0.19 mmol) gave the title compound as a white solid (0.034 g, 49%). m/z (ES+) 459 (100% M+).

Sources & evidence

ORD record
ord-594655cb614b4e448585a2a3ccd8bd43
Source dataset
uspto-grants-2007_05
Patent number
US07220757B2

Reaction notes

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