Hydrochloric Acid → HCID 21100220, compound

Participants

Reaction Conditions

Reaction Steps

To 6.51 mmol 2-cyclobutylmethoxy-5-methanesulfonyl-benzoic acid methyl ester in 20 ml tetrahydrofuran was added 40 mmol 2 N aq NaOH solution and the reaction mixture was stirred at 60° C. for 2 hours. After such time the reaction mixture was acidified by addition of concentrated HCl and extracted twice with dichloromethane. The combined organic phases were dried over sodium sulfate and concentrated in vacuo. The residue was triturated in ether to give the title compound as a white solid (40% over 2 steps). MS (m/e): 283.3 ([M−H]−, 100%).

Provenance & Evidence