HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1352256Generated: October 31, 2026
Potassium Carbonate → 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid methyl ester
https://huagongshe.com/reaction/1352256
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Hydroxy-5-methylsulfonylbenzoic acid methyl ester | HCID 23503163 | — |
| Reactant | 1, 1, 1-Trifluoropropan-2-yl trifluoromethanesulfonatc | HCID 57445280 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid methyl ester | HCID 58863350 | — |
Reaction Steps
A mixture of 21.7 mmol 2-hydroxy-5-methanesulfonyl-benzoic acid methyl ester (WO 2002074774), 32.5 mmol rac-trifluoro-methanesulfonic acid 2,2,2-trifluoro-1-methyl-ethyl ester [212556-43-9] and 43.4 mmol potassium carbonate in 87 ml DMF was stirred at 80° C. for 48 hours. After cooling to room temperature, the mixture was concentrated in vacuo, resuspended in water and stirred for 1 hour. Filtration yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07220744B2 |
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| Source dataset | uspto-grants-2007_05 |
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| ORD ID | ord-2adc796d7ecb4e72b592be45e7ea4651 |
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| Source note | uspto-grants-2007_05 |
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