HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 21100267, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 1-(5-Bromo-1,3-thiazol-2-yl)piperazine | HCID 18423006 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 21100267 | HCID 21100267 | 87% |
Reaction Steps
To a solution of 0.31 mmol 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) in 7 ml tetrahydrofuran were added successively 0.46 mmol TBTU, 1.24 mmol N-ethyldiisopropylamine and 0.34 mmol 1-(5-bromo-thiazol-2-yl)-piperazine. The reaction mixture was stirred at RT for 16 h and then concentrated in vacuo. Chromatography (SiO2, ethyl acetate/heptane) afforded the title compound as a white foam (yield 87%). MS (m/e): 490.3 ({81Br}M+H+, 100%), 488.3 ({79Br}M+H+, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-033b7f7342314271b0d3fd3da885a407 |
| Source note | uspto-grants-2007_05 |