1-(4-Methyl-1,3-thiazol-2-yl)piperazine → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(4-methyl-thiazol-2-yl)-piperazin-1-yl]-methanone

HRID 1352279Notes

Reaction equation

HRID 1352279 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[CH3:18][C:19]1[N:20]=[C:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[S:22][CH:23]=1>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:27]1[CH2:28][CH2:29][N:24]([C:21]2[S:22][CH:23]=[C:19]([CH3:18])[N:20]=2)[CH2:25][CH2:26]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 144798721-(4-Methyl-1,3-thiazol-2-yl)piperazineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 21100240(2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(4-methyl-thiazol-2-yl)-piperazin-1-yl]-methanoneYield 87%

Procedure

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(4-methyl-thiazol-2-yl)-piperazine. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as an amorphous yellow solid (yield 87%). MS (m/e): 424.1 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-59c7c933ebc84d5eb6dd6ad2dd6d1fa7
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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