HCID 21100220, compound → HCID 11712312, compound

HRID 1352295Notes

Reaction equation

HRID 1352295 reaction equation
[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:8]=2[C:9]([OH:11])=O)[CH2:4][CH2:3][CH2:2]1.[N:20]1([C:26]2[S:27][C:28]([C:31]#[N:32])=[CH:29][N:30]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[CH:1]1([CH2:5][O:6][C:7]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][C:8]=2[C:9]([N:23]2[CH2:24][CH2:25][N:20]([C:26]3[S:27][C:28]([C:31]#[N:32])=[CH:29][N:30]=3)[CH2:21][CH2:22]2)=[O:11])[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 21100220HCID 21100220, compoundHCID 211002572-Piperazin-1-yl-thiazole-5-carbonitrile

Product 1

HCID 11712312HCID 11712312, compoundYield 61%

Procedure

Prepared in analogy to example 1 (b) from 2-cyclobutylmethoxy-5-methanesulfonyl-benzoic acid (Example A6) and 2-piperazin-1-yl-thiazole-5-carbonitrile (Example 6(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a white crystalline solid (yield 61%). MS (m/e): 461.3 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-597b0631f06043d6894f326f719356e5
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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