HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Disulfide → 4-(5-Methylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Disulfide | HCID 12232 | — |
| Reactant | Tert-butyl 4-(5-bromo-1,3-thiazol-2-yl)piperazine-1-carboxylate | HCID 34180719 | — |
| Product | 4-(5-Methylsulfanyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 68406778 | 78% |
Reaction Steps
Prepared in analogy to example 4 (b) from 4-(5-bromo-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester (Example 4(a)) and dimethyl disulphide. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to afford the title compound as a yellow crystalline solid (yield 78%). MS (m/e): 316.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-026f3f60fbe4417ca396988e36afa285 |
| Source note | uspto-grants-2007_05 |