HCID 21100187, compound → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(5-methanesulfonyl-thiazol-2-yl)-piperazin-1-yl]-methanone

HRID 1352304Notes

Reaction equation

HRID 1352304 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[CH3:19][S:20]([C:23]1[S:27][C:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:25][CH:24]=1)(=[O:22])=[O:21]>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:31]1[CH2:32][CH2:33][N:28]([C:26]2[S:27][C:23]([S:20]([CH3:19])(=[O:22])=[O:21])=[CH:24][N:25]=2)[CH2:29][CH2:30]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 21100187HCID 21100187, compoundHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 21100243(2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(5-methanesulfonyl-thiazol-2-yl)-piperazin-1-yl]-methanoneYield 43%

Procedure

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(5-methanesulfonyl-thiazol-2-yl)-piperazine hydrochloride. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white crystalline solid (yield 43%). MS (m/e): 488.1 (M+H+, 100%), 505.0 (M+NH4+, 75%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

Sources & evidence

ORD record
ord-2516bdce58a04167bdc41feff94be1e9
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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