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HRID1352306

反应详情

EQUATION

反应方程式

HRID 1352306 的结构方程式

REACTANTS

反应物

2
结构：CS(=O)(=O)c1cnc(N2CCNCC2)s1.Cl
HCID21100187

未命名化合物

结构：CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)O)c1
HCID21100228

2-(Cyclopropylmethoxy)-5-(methylsulfonyl)benzoic acid

C12H14O5S

PRODUCTS

生成物

1
结构：CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3ncc(S(C)(=O)=O)s3)CC2)c1
HCID21100229

未命名化合物

收率 36%

PROCEDURE

实验过程

Prepared in analogy to example 1 (b) from 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (Example A5) and 1-(5-methanesulfonyl-thiazol-2-yl)-piperazine hydrochloride (Example 21(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a yellow crystalline solid (yield 36%). MS (m/e): 500.1 (M+H+, 100%), 517.2 (M+NH4+, 69%).

WORKUP

后处理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)