1-(5-Ethanesulfonyl-thiazol-2-yl)-piperazine hydrochloride → [4-(5-Ethanesulfonyl-thiazol-2-yl)-piperazin-1-yl]-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Participants

Reaction Steps

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(5-ethanesulfonyl-thiazol-2-yl)-piperazine hydrochloride (Example 32(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a white crystalline solid (yield 71%). MS (m/e): 502.3 (M+H+, 100%), 519.3 (M+NH4+, 82%).

Provenance & Evidence