1-(5-Ethanesulfonyl-thiazol-2-yl)-piperazine hydrochloride → (2-Cyclopentyloxy-5-methanesulfonyl-phenyl)-[4-(5-ethanesulfonyl-thiazol-2-yl)-piperazin-1-yl]-methanone

Participants

Reaction Steps

Prepared in analogy to example 1 (b) from 2-cyclopentyloxy-5-methanesulfonyl-benzoic acid (Example A4) and 1-(5-ethanesulfonyl-thiazol-2-yl)-piperazine hydrochloride (Example 32(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a white crystalline solid (yield 77%). MS (m/e): 528.3 (M+H+, 35%), 545.4 (M+NH4+, 100%).

Provenance & Evidence