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HRID1352327

反应详情

EQUATION

反应方程式

HRID 1352327 的结构方程式

REACTANTS

反应物

2
结构：CCCCS(=O)(=O)c1cnc(N2CCNCC2)s1.Cl
HCID21100183

未命名化合物

结构：CS(=O)(=O)c1ccc(OCC(F)(F)F)c(C(=O)O)c1
HCID21100312

未命名化合物

PRODUCTS

生成物

1
结构：CCCCS(=O)(=O)c1cnc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3OCC(F)(F)F)CC2)s1
HCID21100270

{4-[5-(Butane-1-sulfonyl)-thiazol-2-yl]-piperazin-1-yl}-[5-methanesulfonyl-2-(2,2,2-trifluoro-ethoxy)-phenyl]-methanone

C21H26F3N3O6S3

收率 63%

PROCEDURE

实验过程

Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-ethoxy)-benzoic acid (Example A3) and 1-[5-(butane-1-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride (Example 38(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a white crystalline solid (yield 63%). MS (m/e): 570.4 (M+H+, 15%), 587.3 (M+NH4+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)