HCID 21100183, compound → HCID 21100271, compound

HRID 1352330Notes

Reaction equation

HRID 1352330 reaction equation
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].Cl.[CH2:21]([S:25]([C:28]1[S:32][C:31]([N:33]2[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]2)=[N:30][CH:29]=1)(=[O:27])=[O:26])[CH2:22][CH2:23][CH3:24]>>[CH2:21]([S:25]([C:28]1[S:32][C:31]([N:33]2[CH2:38][CH2:37][N:36]([C:10]([C:9]3[CH:13]=[C:5]([S:2]([CH3:1])(=[O:3])=[O:4])[CH:6]=[CH:7][C:8]=3[N:14]3[CH2:19][CH2:18][O:17][CH2:16][CH2:15]3)=[O:12])[CH2:35][CH2:34]2)=[N:30][CH:29]=1)(=[O:27])=[O:26])[CH2:22][CH2:23][CH3:24]

Participants

3

Reactant 2

HCID 21100183HCID 21100183, compoundHCID 211003195-(Methanesulfonyl)-2-(morpholin-4-yl)benzoic acid

Product 1

HCID 21100271HCID 21100271, compoundYield 60%

Procedure

Prepared in analogy to example 1 (b) from 5-Methanesulfonyl-2-morpholin-4-yl-benzoic acid (Example A13) and 1-[5-(butane-1-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride (Example 38(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a light red crystalline solid (yield 60%). MS (m/e): 557.2 (M+H+, 65%), 574.4 (M+NH4+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-df84ca0f5e714498ac1ab81f96dc1405
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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