HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21100193, compound → HCID 21100309, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 21100193 | HCID 21100193 | — |
| Reactant | 5-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid | HCID 21100306 | — |
| Product | HCID 21100309 | HCID 21100309 | 68% |
Reaction Steps
Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example A2) and 1-[5-(pyridine-2-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride (Example 45(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 68%). MS (m/e): 605.0 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-261432af04284adbbfc06e4b879d7acd |
| Source note | uspto-grants-2007_05 |