1-[5-(Pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride → [5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-{4-[5-(pyridine-3-sulfonyl)-thiazol-2-yl]-piperazin-1-yl}-methanone

Participants

Reaction Steps

Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example A2) and 1-[5-(pyridine-3-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride (Example 46(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a light brown crystalline solid (yield 49%). MS (m/e): 605.2 (M+H+, 100%).

Provenance & Evidence