3-Bromo-1,1,1-trifluoro-2-propanone → 1-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]piperazine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of 6.89 mmol 1-piperazinecarbothioamide in 10 ml ethanol was added 8.26 mmol 3-bromo-1,1,1-trifluoroacetone and the mixture was heated at 70° C. for 2 h. The mixture was then concentrated in vacuo and the residue resuspended in dichloromethane. Insoluble material was removed by filtration and the filtrate was concentrated in vacuo. Chromatography (SiO2, methanol/dichloromethane) afforded the title compound as a yellow crystalline solid (yield 41%). MS (m/e): 238.1 (M+H+, 100%).

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