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HRID1352341

反应详情

EQUATION

反应方程式

HRID 1352341 的结构方程式

REACTANTS

反应物

2
结构：FC(F)(F)c1csc(N2CCNCC2)n1
HCID13747810

1-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]piperazine

C8H10F3N3S

结构：CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
HCID21100237

2-(1-Methylethoxy)-5-(methylsulfonyl)benzoic acid

C11H14O5S

PRODUCTS

生成物

1
结构：CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nc(C(F)(F)F)cs2)CC1
HCID21100241

未命名化合物

收率 55%

PROCEDURE

实验过程

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(4-trifluoromethyl-thiazol-2-yl)-piperazine. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the title compound as a crystalline white solid (yield 55%). MS (m/e): 478.0 (M+H+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)