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HRID1352342

反应详情

EQUATION

反应方程式

HRID 1352342 的结构方程式

REACTANTS

反应物

2
结构：FC(F)(F)c1csc(N2CCNCC2)n1
HCID13747810

1-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]piperazine

C8H10F3N3S

结构：CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)O)C(F)(F)F
HCID21100306

5-(Methylsulfonyl)-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

C11H11F3O5S

PRODUCTS

生成物

1
结构：CC(Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nc(C(F)(F)F)cs2)CC1)C(F)(F)F
HCID21100308

未命名化合物

收率 48%

PROCEDURE

实验过程

Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example A2) and 1-(4-trifluoromethyl-thiazol-2-yl)-piperazine (Example 49(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the title compound as a crystalline white solid (yield 48%). MS (m/e): 531.8 (M+H+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)