1-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]piperazine → [5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[4-(4-trifluoromethyl-thiazol-2-yl)-piperazin-1-yl]-methanone

HRID 1352342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1352342
[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][CH:15]([CH3:20])[C:16]([F:19])([F:18])[F:17])=[C:9]([CH:13]=1)[C:10]([OH:12])=O)(=[O:4])=[O:3].[F:21][C:22]([F:35])([F:34])[C:23]1[N:24]=[C:25]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[S:26][CH:27]=1>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:14][CH:15]([CH3:20])[C:16]([F:19])([F:18])[F:17])=[C:9]([C:10]([N:31]2[CH2:32][CH2:33][N:28]([C:25]3[S:26][CH:27]=[C:23]([C:22]([F:35])([F:21])[F:34])[N:24]=3)[CH2:29][CH2:30]2)=[O:12])[CH:13]=1)(=[O:3])=[O:4]

Komponenten

3

Edukt 2

HCID 137478101-[4-(Trifluoromethyl)-1,3-thiazol-2-yl]piperazineHCID 211003065-Methylsulfonyl-2-(2,2,2-trifluoro-1-methylethoxy)benzoic acid

Produkt 1

HCID 21100308[5-Methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-[4-(4-trifluoromethyl-thiazol-2-yl)-piperazin-1-yl]-methanoneAusbeute 48 %

Versuchsvorschrift

Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example A2) and 1-(4-trifluoromethyl-thiazol-2-yl)-piperazine (Example 49(a)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the title compound as a crystalline white solid (yield 48%). MS (m/e): 531.8 (M+H+, 100%).

Aufarbeitung

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Quellen und Nachweise

ORD-Eintrag
ord-fc30aeb3f11041c2b14954a593d6fcba
Quelldatensatz
uspto-grants-2007_05
Patentnummer
US07220744B2

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