HCID 21100197, compound → HCID 21100311, compound

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Reaction Steps

Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example A2) and 1-[5-(pyridine-4-sulfonyl)-thiazol-2-yl]-piperazine hydrochloride (Example 52(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in ether to yield the title compound as a light yellow crystalline solid (yield 32%). MS (m/e): 551.2 (M+H+, 100%).

Provenance & Evidence