HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromo-1,1,1-trifluorobutan-2-one → 1-(5-Methyl-4-trifluoromethyl-thiazol-2-yl)-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromo-1,1,1-trifluorobutan-2-one | HCID 2736410 | — |
| Reactant | 1-Piperazinecarbothioamide | HCID 4739638 | — |
| Product | 1-(5-Methyl-4-trifluoromethyl-thiazol-2-yl)-piperazine | HCID 21100189 | 25% |
Reaction Steps
Prepared in analogy to example 49 (a) from 1-piperazinecarbothioamide and 3-bromo-1,1,1-trifluoro-2-butanone. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white crystalline solid (yield 25%). MS (m/e): 252.1 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-6d1d384eba5b423686f52f4ad5a11fe5 |
| Source note | uspto-grants-2007_05 |