1-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine → (2-Isopropoxy-5-methanesulfonyl-phenyl)-{4-[4-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazin-1-yl}-methanone

Participants

Role	Name	HCID	Charge
Reactant	1-[4-(2,2,2-Trifluoro-ethyl)-thiazol-2-yl]-piperazine	HCID 21100172	—
Reactant	2-Isopropoxy-5-methylsulfonylbenzoic acid	HCID 21100237	—
Product	(2-Isopropoxy-5-methanesulfonyl-phenyl)-{4-[4-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazin-1-yl}-methanone	HCID 21100238	28%

Reaction Steps

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-[4-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazine. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the title compound as a white crystalline solid (yield 28%). MS (m/e): 492.1 (M+H+, 100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07220744B2
Source dataset	uspto-grants-2007_05
ORD ID	ord-cf56bbe0e30a4e168001d2d9214545ba
Source note	uspto-grants-2007_05