HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → HCID 21100251, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride | HCID 21100200 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Product | HCID 21100251 | HCID 21100251 | 28% |
Reaction Steps
Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the title compound as a white crystalline solid (yield 28%). MS (m/e): 478.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-ef22794615244b74985684cdabe2d438 |
| Source note | uspto-grants-2007_05 |