huagongshe.com
HRID1352368

反应详情

EQUATION

反应方程式

HRID 1352368 的结构方程式

REACTANTS

反应物

2
结构：Cl.FC(F)(F)c1cnc(N2CCNCC2)s1
HCID21100200

未命名化合物

结构：C[C@@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)O)C(F)(F)F
HCID58863354

5-(Methylsulfonyl)-2-[(1R)-2,2,2-trifluoro-1-methylethoxy]benzoic acid

C11H11F3O5S

PRODUCTS

生成物

1
结构：C[C@@H](Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)s2)CC1)C(F)(F)F
HCID11570050

未命名化合物

收率 57%

PROCEDURE

实验过程

Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (Example A16) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the title compound as an off-white crystalline solid (yield 57%). MS (m/e): 532.0 (M+H+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)