HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 21100179, compound → HCID 21100305, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 21100179 | HCID 21100179 | — |
| Reactant | 5-Methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-benzoic acid | HCID 21100304 | — |
| Product | HCID 21100305 | HCID 21100305 | 27% |
Reaction Steps
Prepared in analogy to example 1 (b) from 5-methanesulfonyl-2-(2,2,2-trifluoro-1,1-dimethyl-ethoxy)-benzoic acid (Example A14) and 1-[5-(2,2,2-trifluoro-ethyl)-thiazol-2-yl]-piperazine hydrochloride (Example 69(e)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as a white crystalline solid (yield 27%). MS (m/e): 560.3 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07220744B2 |
| Source dataset | uspto-grants-2007_05 |
| ORD ID | ord-fce52218258a4c1693911142da94b428 |
| Source note | uspto-grants-2007_05 |