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HRID1352383

反应详情

EQUATION

反应方程式

HRID 1352383 的结构方程式

REACTANTS

反应物

2
结构：Cl.FC(F)(F)c1cnc(N2CCNCC2)s1
HCID21100200

未命名化合物

结构：CC[C@H](C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
HCID58863355

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2ncc(C(F)(F)F)s2)CC1
HCID11634583

未命名化合物

收率 13%

PROCEDURE

实验过程

Prepared in analogy to example 1 (b) from 2-((S)-sec-butoxy)-5-methanesulfonyl-benzoic acid (Example A21) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by reversed phase HPLC (acetonitrile/water) followed by trituration in ether to yield the title compound as an off-white crystalline solid (yield 13%). MS (m/e): 492.4 (M+H+, 100%).

WORKUP

后处理

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)