Hydrochloric Acid → 1-(2-Piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 0.58 mmol 4-(5-propionyl-thiazol-2-yl)-piperazine-1-carboxylic acid tert-butyl ester in 6 ml dioxane was added dropwise 8.76 mmol hydrogen chloride solution (4 M in dioxane) and the mixture was stirred at 90° C. for 90 min. The reaction mixture was then cooled to 0° C. and diluted with ether. The resulting crystals were collected by filtration and washed with ether to afford the title compound as a white crystalline solid (yield 99%). MS (m/e): 226.4 (M+H+, 100%).

Provenance & Evidence