HCID 21100206, compound → HCID 21100168, compound

HRID 1352398Notes

Reaction equation

HRID 1352398 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[CH3:19][C:20]([CH3:35])([CH3:34])[C:21]([C:23]1[S:27][C:26]([N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[N:25][CH:24]=1)=[O:22]>>[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:31]1[CH2:32][CH2:33][N:28]([C:26]2[S:27][C:23]([C:21](=[O:22])[C:20]([CH3:34])([CH3:19])[CH3:35])=[CH:24][N:25]=2)[CH2:29][CH2:30]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 21100206HCID 21100206, compoundHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 21100168HCID 21100168, compoundYield 28%

Procedure

Prepared in analogy to example 1 (b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 2,2-dimethyl-1-(2-piperazin-1-yl-thiazol-5-yl)-propan-1-one hydrochloride. The crude material was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a light brown crystalline solid (yield 28%). MS (m/e): 494.1 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, methanol/dichloromethane)

Sources & evidence

ORD record
ord-279eae028a9e4ec69e77d92157d42ff4
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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