1-(5-Trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride → (2-Isopropylsulfanyl-5-methanesulfonyl-phenyl)-[4-(5-trifluoromethyl-thiazol-2-yl)-piperazin-1-yl]-methanone

Participants

Reaction Steps

Prepared in analogy to example 1 (b) from 2-isopropylsulfanyl-5-methanesulfonyl-benzoic acid (Example A22) and 1-(5-trifluoromethyl-thiazol-2-yl)-piperazine hydrochloride (Example 58(c)). The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) followed by trituration in pentane to yield the tide compound as a white foam (yield 50%). MS (m/e): 494.4 (M+H+, 100%).

Provenance & Evidence