1-(3-Phenyl-(1,2,4)thiadiazol-5-yl)-piperazine → HCID 21100253, compound

HRID 1352406Notes

Reaction equation

HRID 1352406 reaction equation
[CH:1]([S:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].[C:18]1([C:24]2[N:28]=[C:27]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)[S:26][N:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH:1]([S:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([N:32]1[CH2:33][CH2:34][N:29]([C:27]2[S:26][N:25]=[C:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[N:28]=2)[CH2:30][CH2:31]1)=[O:9])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 27777601-(3-Phenyl-(1,2,4)thiadiazol-5-yl)-piperazineHCID 211002522-Isopropylsulfanyl-5-methanesulfonyl-benzoic acid

Product 1

HCID 21100253HCID 21100253, compoundYield 83%

Procedure

Prepared in analogy to example 1 (b) from 2-isopropylsulfanyl-5-methanesulfonyl-benzoic acid (Example A22) and 3-phenyl-5-piperazino-1,2,4-thiadiazole. The crude material was purified by chromatography (SiO2, ethyl acetate/heptane) to yield the title compound as an off-white solid (yield 83%). MS (m/e): 503.1 (M+H+, 100%).

Workup

  1. customThe crude material was purified by chromatography (SiO2, ethyl acetate/heptane)

Sources & evidence

ORD record
ord-a1a5bc3b55af461bb316d49ad6a4f4c7
Source dataset
uspto-grants-2007_05
Patent number
US07220744B2

Reaction notes

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