3-Bromo-2,2-dimethyl-1-propanol → 3-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-one

HRID 1352440Notes

Reaction equation

HRID 1352440 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1.Br[CH2:20][C:21]([CH3:25])([CH3:24])[CH2:22][OH:23]>>[OH:23][CH2:22][C:21]([CH3:25])([CH3:24])[CH2:20][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 1425013-Bromo-2,2-dimethyl-1-propanolHCID 230821133-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride

Product 1

HCID 103135603-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-oneYield 15.2%

Procedure

By the reaction in the same manner as in Example 2a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (510 mg) and 3-bromo-2,2-dimethyl-1-propanol (474 mg), 3-[1-(3-hydroxy-2,2-dimethylpropyl)piperidin-4-yl]-2H-isoquinolin-1-one (92 mg) was obtained.

Workup

  1. customBy the reaction in the same manner as in Example 2a

Sources & evidence

ORD record
ord-55cfaaf3c7f94b169a9a20c53b5e67a8
Source dataset
uspto-grants-2007_05
Patent number
US07220759B2

Reaction notes

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