HCID 22931050, compound → HCID 58863436, compound

HRID 1352479Notes

Reaction equation

HRID 1352479 reaction equation
C([N:3]([CH2:14][CH3:15])[C:4](=[O:13])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12])C.[OH:16][C@@H:17]1[CH2:21][CH2:20][N:19]([CH2:22]CC(N(OC)C)=O)[CH2:18]1>>[F:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]2[C:6]=1[CH:12]=[C:14]([CH2:15][CH2:22][N:19]1[CH2:20][CH2:21][C@@H:17]([OH:16])[CH2:18]1)[NH:3][C:4]2=[O:13]

Participants

3

Reactant 2

HCID 22931050HCID 22931050, compoundHCID 58863437HCID 58863437, compound

Product 1

HCID 58863436HCID 58863436, compoundYield 26%

Procedure

In the same manner as in Example 16b and using N,N-diethyl-3-fluoro-2-methylbenzamide (3.46 g) and (R)-3-(3-hydroxypyrrolidin-1-yl)-N-methoxy-N-methylpropanamide (3.36 g), (R)-5-fluoro-3-[2-(3-hydroxypyrrolidin-1-yl)ethyl]-2H-isoquinolin-1-one (1.19 g) was obtained.

Sources & evidence

ORD record
ord-43701b9e1d32456a8bb81fa4ade5908f
Source dataset
uspto-grants-2007_05
Patent number
US07220759B2

Reaction notes

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