反应详情

To a solution of sodium methoxide (33 g) in methanol (130 ml), 4-chloroquinoline (10 g) was added under stirring. The mixture was heated under reflux for 6 hours. After cooling, the reaction mixture was concentrated, then dissolved in dichloromethane (250 ml) and washed with water (250 ml). The organic layer was dried over sodium sulfate. The solvent was evaporated to give a yellow oil (7.39 g, 76% yield) which was not purified.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 6 hours
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated
5. dissolutiondissolved in dichloromethane (250 ml)
6. washwashed with water (250 ml)
7. dry with materialThe organic layer was dried over sodium sulfate
8. customThe solvent was evaporated